The Application and Research of Probiotics in the Treatment of Diabetes
DOI:
https://doi.org/10.53469/wjimt.2024.07(05).18Keywords:
Probiotics, Diabetes, Gut microbiome, Complications of diabetesAbstract
This review explores the application and research progress of probiotics in the treatment of diabetes. With the rising incidence of diabetes, traditional treatments face numerous challenges, including side effects of medications and poor patient compliance. As a novel therapeutic approach, probiotics have shown potential in improving glycemic control, enhancing insulin sensitivity, and lowering inflammation levels. Research indicates that probiotics can regulate the gut microbiome, improve intestinal barrier function, promote nutrient absorption, and thus affect overall metabolic status. Furthermore, the antioxidant properties of probiotics have shown positive effects in protecting pancreatic cells and alleviating diabetes complications. Recent clinical trials have further supported the application of probiotics in diabetes management, especially in improving renal function, neuropathy, and cardiovascular health. Despite the optimistic results of existing studies, more high-quality randomized controlled trials are needed to establish the specific effects and optimal use strategies of different probiotics. This review provides a theoretical basis for future research and emphasizes the importance and potential of probiotics in the treatment of diabetes.
References
Home, Resources, diabetes L with, Acknowledgement, FAQs, Contact, et al. IDF Diabetes Atlas 2021 | IDF Diabetes Atlas. https://diabetesatlas.org/atlas/tenth-edition/. Accessed 30 Sep 2024.
American Diabetes Association (2014). Diagnosis and classification of diabetes mellitus. Diabetes Care, 37 Suppl 1:S81-90.
American Diabetes Association (2013). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 36:S67–S74.
Kharroubi AT, Darwish HM (2015). Diabetes mellitus: The epidemic of the century. World J Diabetes, 6:850–867.
Cai Z, Wu X, Song Z, Sun S, Su Y, Wang T, et al. (2023). Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis. Cell Discov, 9:104.
Gedawy A, Martinez J, Al-Salami H, Dass CR (2018). Oral insulin delivery: existing barriers and current counter-strategies. J Pharm Pharmacol, 70:197–213.
Nissen SE, Wolski K (2007). Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med, 356:2457–2471.
Kim Y-G, Kim S, Han SJ, Kim DJ, Lee K-W, Kim HJ (2018). Dipeptidyl Peptidase-4 Inhibitors and the Risk of Pancreatitis in Patients with Type 2 Diabetes Mellitus: A Population-Based Cohort Study. J Diabetes Res, 2018:5246976.
Wilding J, Fernando K, Milne N, Evans M, Ali A, Bain S, et al. (2018). SGLT2 Inhibitors in Type 2 Diabetes Management: Key Evidence and Implications for Clinical Practice. Diabetes Ther, 9:1757–1773.
Kim S-K, Guevarra RB, Kim Y-T, Kwon J, Kim H, Cho JH, et al. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol, 29:1335–1340.
Markowiak P, ?li?ewska K (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9:1021.
Capurso L (2019). Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol, 53 Suppl 1:S1–S41.
Sedighi M, Razavi S, Navab-Moghadam F, Khamseh ME, Alaei-Shahmiri F, Mehrtash A, et al. (2017). Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals. Microb Pathog, 111:362–369.
Mc P, Gi S (2018). Mechanisms of Insulin Action and Insulin Resistance. Physiological reviews. doi: 10.1152/physrev.00063.2017.
Cani PD, Everard A (2016). Talking microbes: When gut bacteria interact with diet and host organs. Mol Nutr Food Res, 60:58–66.
Yadav H, Jain S, Sinha PR (2007). Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition, 23:62–68.
E Y, L B, I I, R I, M M, Js Y, et al. (2023). Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis. Nutrients. doi: 10.3390/nu15071633.
P M-K, K ? (2020). The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. doi: 10.3390/nu12041107.
S P, Y J, Hy J, H P, J K, Sh C, et al. (2017). Lactobacillus plantarum HAC01 regulates gut microbiota and adipose tissue accumulation in a diet-induced obesity murine model. Applied microbiology and biotechnology. doi: 10.1007/s00253-016-7953-2.
Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer R-JM, et al. (2010). Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol, 298:G851-859.
Kang Y, Kang X, Yang H, Liu H, Yang X, Liu Q, et al. (2022). Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability. Pharmacological Research, 175:106020.
Li X, Wang E, Yin B, Fang D, Chen P, Wang G, et al. (2017). Effects of Lactobacillus casei CCFM419 on insulin resistance and gut microbiota in type 2 diabetic mice. Benef Microbes, 8:421–432.
Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R (2020). Type 2 Diabetes and its Impact on the Immune System. Curr Diabetes Rev, 16:442–449.
Dolpady J, Sorini C, Di Pietro C, Cosorich I, Ferrarese R, Saita D, et al. (2016). Oral Probiotic VSL#3 Prevents Autoimmune Diabetes by Modulating Microbiota and Promoting Indoleamine 2,3-Dioxygenase-Enriched Tolerogenic Intestinal Environment. Journal of Diabetes Research, 2016:7569431.
Yadav H, Lee J-H, Lloyd J, Walter P, Rane SG (2013). Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion *. Journal of Biological Chemistry, 288:25088–25097.
Sharma VK, Singh TG, Dhiman S, Garg N (2022). Mechanisms of Beneficial Effects of Probiotics in Diabetes Mellitus. In: Chopra K, Bishnoi M, Kondepudi KK, editors Probiotic Research in Therapeutics: Volume 5: Metabolic Diseases and Gut Bacteria. Singapore: Springer Nature, 97–124.
Valladares R, Sankar D, Li N, Williams E, Lai K-K, Abdelgeliel AS, et al. (2010). Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS One, 5:e10507.
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, et al. (2018). Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science, 359:1151–1156.
Stenman L k., Waget A, Garret C, Klopp P, Burcelin R, Lahtinen S (2014). Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Beneficial Microbes, 5:437–445.
Zhou X, Shang G, Tan Q, He Q, Tan X, Park K-Y, et al. (2021). Effect of Lactobacillus fermentum TKSN041 on improving streptozotocin-induced type 2 diabetes in rats. Food Funct, 12:7938–7953.
Kang Q, Yang C (2020). Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol, 37:101799.
Teng Y, Wang Y, Tian Y, Chen Y, Guan W, Piao C, et al. (2020). Lactobacillus plantarum LP104 ameliorates hyperlipidemia induced by AMPK pathways in C57BL/6N mice fed high-fat diet. Journal of Functional Foods, 64:103665.
Ríos-Covián D, Ruas-Madiedo P, Margolles A, Gueimonde M, de los Reyes-Gavilán CG, Salazar N (2016). Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. doi: 10.3389/fmicb.2016.00185.
Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V (2012). Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition, 28:539–543.
Huang Y, Qu H, Liu D, Wa Y, Sang J, Yin B, et al. (2020). The effect of Lactobacillus fermentum DALI02 in reducing the oxidative stress and inflammatory response induced by high-fat diet of rats. RSC Advances, 10:34396–34402.
A NE-D, A E, Hf A, G A, M F (2022). Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutrition research (New York, NY). doi: 10.1016/j.nutres.2022.10.003.
Kobyliak N, Khomenko M, Falalyeyeva T, Fedchenko A, Savchuk O, Tseyslyer Y, et al. (2023). Probiotics for pancreatic β-cell function: from possible mechanism of action to assessment of effectiveness. Crit Rev Microbiol, 1–21.
Rs M, Jj A, J N, A T, S N (2019). Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study. PloS one. doi: 10.1371/journal.pone.0225168.
Zhang C, jiang J, Wang C, Li S, Yu L, Tian F, et al. (2022). Meta-analysis of randomized controlled trials of the effects of probiotics on type 2 diabetes in adults. Clinical Nutrition, 41:365–373.
Perraudeau F, McMurdie P, Bullard J, Cheng A, Cutcliffe C, Deo A, et al. (2020). Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Research and Care, 8:e001319.
Jiang H, Zhang Y, Xu D, Wang Q (2021). Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study. Journal of Clinical Laboratory Analysis, 35:e23650.
Hsu Y-C, Huang Y-Y, Tsai S-Y, Kuo Y-W, Lin J-H, Ho H-H, et al. (2024). Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study. Nutrients, 16:16.
Ayesha IE, Monson NR, Klair N, Patel U, Saxena A, Patel D, et al. (2023). Probiotics and Their Role in the Management of Type 2 Diabetes Mellitus (Short-Term Versus Long-Term Effect): A Systematic Review and Meta-Analysis. Cureus, 15:e46741.